People

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Andrew Belmont

Principal Investigator

Professor, Department of Cell and Developmental Biology,

Institute of Genomic Biology,

Center for Biophysics and Quantitative Biology

University of Illinois, Urbana Champaign

Postdoc      University of California, San Francisco

Postdoc      Johns Hopkins University

M.D./PhD   Temple University Medicine/Biophysics

AB               Princeton University, Physics

I’ve always been a very visual person.  Much of my research has been driven simply by wanting to answer the obvious questions that spring to mind while looking at microscopy images of the cell nucleus.  Recently, our laboratory has ventured into sequencing based methods, but ones we develop and/or modify to better predict and/or interpret what we might actually see looking in the microscope. 

Hobbies/Passion: My main hobby is pretty much trying to come up with ideas for how to answer some of these questions.  My work is everything else needed to implement whatever is needed to answer these questions, including funding, recruiting, and working with the research group that will actually provide the answers to these questions.

Additional hobbies include skiing, fly fishing, playing basketball poorly, and, most recently, trying to get smiles and laughs from my three grandchildren.

Email ID: asbel@illinois.edu

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Pankaj Chaturvedi

Research Scientist, PhD

As a trained molecular biologist, I am exploring the principles of nuclear organization and function through cell culture-based systems. Currently, I am involved in elucidating the importance of nuclear landmarks such as Nuclear Speckles, Nuclear Lamina, Nucleolus, and Chromocenters in determining gene expression in mammalian cell lines. The ultimate goal of my research is to leverage this understanding to enhance long-term stable gene expression, aiming to drive forward biotechnological applications such as gene therapy and bio-pharmaceuticals.

 

Hobbies/Passion: Gardening, Photography

 

Email ID: pankajch@illinois.edu

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Neha Chivukula

Graduate Student

My work deals with identifying new nuclear niches where a subset of active genes are positioned and understanding the functional significance of this gene positioning.

 

Email ID: nehac6@illinois.edu

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Gabriela Hernandez Gonzalez

Graduate Student

My research focuses on understanding how certain genes, like HSPA1, are positioned near nuclear speckles to enhance gene expression, with a particular emphasis on chromosome movement and dynamics. We hypothesize that the stable positioning of HSPA1 genes near speckles arises from a combination of transcription-dependent anchoring and long-range chromosome movements driven by specific speckle condensates.

 

Hobbies/Passion: When I’m not in the lab, I love traveling and reading, especially fantasy novels. In my downtime, I also enjoy playing video games and experimenting with new bread recipes, particularly from Italy and Germany.

 

Email ID: gah3@illinois.edu

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Purnam Ghosh

Graduate Student

Can certain activators reposition genomic regions to nuclear speckles? If so, how do they do it? What does it mean for a repositioned locus and its flanking regions to be near a speckle? These are some exciting problems I am trying to address!

 

Hobbies/Passion: I play Indian (Hindustani) Classical music on the violin and listen to music in my free time.

 

Email ID: purnamg2@illinois.edu

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Jiah Kim

Postdoc, Phd

I am interested in the dynamics of nuclear speckles and their role in transcription regulation.

 

Email ID: jiahkim@illinois.edu

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Shuting Liu

Graduate Student

We are developing a new NGS method to measure chromosome compaction in cells.

 

Hobbies/Passion: Bouldering, Game, Chinchilla

 

Email ID: shuting8@illinois.edu

 

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Saireet Misra

Graduate Student

My research focuses on investigating the dynamics of nuclear speckle protein trafficking to and from actively transcribing chromatin and its role in gene expression regulation. Additionally, I am interested in exploring the spatiotemporal functions of nuclear condensates in modulating gene expression.

 

Hobbies/Passion: I love playing the violin, especially Western classical music.

 

Email ID: saireet2@illinois.edu

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Shreyasi Neogi

Graduate Student

My project aims to observe how physiological stimuli influence the movement and association of endogenous genes with these active nuclear niches and to correlate the altered association with transcription, followed by determining the functional significance of such phenomena.

 

Hobbies/Passion: I like to spend my free time reading and writing (non-academic). Other than that I am passionate about dancing.

 

Email ID: sneogi2@illinois.edu

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Che Yang

Graduate Student

My research aims to understand the dynamics of DNA to nuclear speckle based on a particular TSA-seq pattern. This aim will be achieved by modifying U2OS cell line with SON tagged EGFP, expressing TetR-Halo and Knock-in TetO into loci of interest, then using super resolution microscope to visualize the modified cell line.

 

Email ID: cheyang2@illinois.edu

Lab Alumni

 

  • Pradeep Kumar
  • Omid Gholamalamdari
  • Ligou Zhang
  • Dr. Joseph Dopie
  • Binhui Zhao
  • Xiang Deng
  • Nimish Khanna
  • Qian Bian
  • Yan Hu
  • Paul Sinclair
  • Igor Kireev
  • Matt Plutz
  • Yuri G Strukov
  • Alena Rego
  • Chien-Hui Chuang
  • Steffen Dietzel
  • Natashe Kireeva
  • Anne E Carpenter
  • Sevinci Memedula
  • Tudorita Tumbar
  • Gang Li
  • Carmen C Robinett